2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Feb 19, 2026DOI: 10.1161/cir.0000000000001415Journal ArticleAHA
Written by: Writing Committee MembersMark A CreagerGeoffrey D BarnesJay GiriDebabrata MukherjeeWilliam Schuyler JonesAllison E BurnettTeresa CarmanAna I CasanegraLana A CastellucciSherrell M ClarkMary CushmanKerstin de WitJennifer M EavesMargaret C FangJoshua B GoldbergStanislav HenkinHillary Johnston-CoxSabeeda KadavathDaniella Kadian-DodovWilliam Brent KeelingAndrew J P KleinJun LiMichael C McDanielLisa K MooresGregory PiazzaKaren S PrengerSteven C PuglieseMona RanadeRachel P RosovskyFarla RussoEric A SecemskyAkhilesh K SistaLeben TeferaIdo WeinbergLauren M WestaferMichael N Young
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JG
Dr. Jay Giri
Interventional Cardiology · HUP
SK
Dr. Sabeeda Kadavath
Interventional & Structural Cards · St. Mary's Regional Health Center
MR
Dr. Mona Ranade
Interventional Radiology · Stanford
Summary
AIM: The "2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults" is a de novo guideline that provides comprehensive recommendations for the evaluation, management, and follow-up of adult patients (≥18 years of age) with acute pulmonary embolism (PE). A key feature of this guideline is the introduction of the AHA/ACC Acute Pulmonary Embolism Clinical Categories, which enhance the precision of severity classification, prognosis assessment, and evidence-based therapeutic decision-making.METHODS: A comprehensive literature search was conducted from February 2024 to October 2024 to identify clinical studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. Select key studies published until April 2025 were added by the guideline writing committee as appropriate.STRUCTURE: The focus of this clinical practice guideline is an evidence-based and patient-centered approach for acute PE evaluation and management of the adult patient. This guideline encompasses the period from the onset of symptoms through clinical follow-up, focusing on risk outcomes assessment, clinical diagnosis of acute PE, appropriate use of adjunctive cardiovascular testing, and management in both the acute and early post-acute phases of PE. It addresses evidence-based diagnostic and management strategies (including pharmacological therapies, advanced interventional therapies, and in-hospital support) for acute PE and associated outcomes.
JG
Dr. Jay Giri
Cardiology · Interventional CardiologyHospital of the University of PennsylvaniajaygPhiladelphia, PA, USA
