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    Overview

    A Liver-Targeted *CIDEB* siRNA in Adults with MASLD

    Nov 8, 2026DOI: 10.1056/nejmc2612905CorrespondenceNEJM

    Written by: Thomas D. Norton, M.D.Jorg Taubel, M.D.Gavin H. Imperato, M.D., Ph.D.Sonya Aziz-Zaman, M.S.Jane Witkin, Pharm.D.Jutta Miller, R.N.Kusha A. Mohammadi, Ph.D.Shunguang Wang, Ph.D.Terri Swanson, M.A.Madison Stoms, Ph.D.Xiping Cheng, Ph.D.Jessica D’Antonio, M.B.A.Shehla Habib, B.S.David Workman, M.B.A.Justin Cho, M.S.Yogesh Patel, Ph.D.Vidya Xavier, M.Pharm.Chao Chen, Ph.D.David J. Smith, Ph.D.Sean Smith, Pharm.D.Susana Pereira, B.S.Donato Forlenza, Pharm.D.Joette Pindar, M.S.Meredith Crosby, Ph.D.Shawn Fidotta, B.S.Mauricio Leal, Ph.D.Fady Tanios, Ph.D.Viktoria Gusarova, Ph.D.Mark Sleeman, Ph.D.Jennifer Hamilton, Ph.D.John Davis, Ph.D.Dinko Gonzalez Trotter, Ph.D.Rong Liu, M.D., Ph.D.Bret Musser, Ph.D.Ed Cox, M.D.Ned Braunstein, M.D.Niek Verweij, Ph.D.Luca A. Lotta, M.D., Ph.D.George D. Yancopoulos, M.D., Ph.D.Aris Baras, M.D.Gary A. Herman, M.D.David J. Lederer, M.D.

    Summary

    A single dose of an siRNA targeting liver expression of CIDEB was associated with a reduction in liver fat of 58 to 80% at week 36 after treatment in persons with metabolic dysfunction–associated steatotic liver disease.
    TNThe New England Journal of Medicine

    The New England Journal of Medicine

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    https://www.nejm.org/
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