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    Overview

    Retatrutide Once Weekly in Adults with Knee Osteoarthritis Pain and Obesity

    Nov 8, 2026DOI: 10.1056/nejmoa2610676Original ArticleNEJM

    Written by: Thomas J. Schnitzer, M.D., Ph.D.David J. Hunter, M.B., B.S., Ph.D.Philip G. Conaghan, M.B., B.S., Ph.D.Arya M. Sharma, M.D., D.Sc.Sue D. Pedersen, M.D.Kaiyi Chen, Ph.D.So Young Park, Ph.D.Nune Makarova, M.D., M.P.H.Kathryn Giblin, M.D.Tammy Forrester, M.S.

    Summary

    The WOMAC pain score and body weight decreased significantly more with retatrutide than with placebo in patients with painful knee osteoarthritis and obesity.
    TNThe New England Journal of Medicine

    The New England Journal of Medicine

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